Top of page E. hirta is a native of tropical America, now widespread at low altitudes throughout the tropics and subtropics. Particularly, the mechanisms of platelet increasing activity have to be identified. Anti-D immune globulin therapy in some instances is used for severe thrombocytopenia , but this is expensive making it challenging for developing nations to afford such a treatment regimen. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Further, this attempt warrants exploring the bioactive compounds and possible mechanisms of action and will pave the way to develop a new antidengue drug lead from E. hirta. Further purification of ethyl acetate fractions of the plant revealed 9 compounds which may exert an antidengue effect individually or synergistically . Consume this tea in moderate amounts only for one week. After cooling and paper-filtration, the decoction is taken by the patient at one glass every hour until the fever subsides. Even though E. hirta has a small amount of phenolic compounds compared to the other plants used for dengue (e.g., Carica papaya), it may be sufficient to exert an effect promoting quality and quantity of platelets. These indicated the folkloric belief of E. hirta as a treatment against dengue. Thus, the present study provides a comprehensive review of studies conducted on the antidengue activity ofE. Sign up here as a reviewer to help fast-track new submissions. The aqueous extracts of Euphorbia hirta was prepared by boiling 20g of powdered … Dengue associated mortality is usually reflected in the increase in the progression of DF patients developing DHF/DS . The severity of dengue is amplified by the lack of effective treatment . Leave and let it stand for 20 minutes. The parts of the plant that … However, the number of studies conducted to validate its antidengue activity was found to be inadequate. PubMed:Phytochemical study and screening for antimicrobial activity of flavonoids of Euphorbia hirta. The ready availability of E. hirta in home gardens has increased its use as a home remedy . The solvents in the extracts were removed via rotary evaporation under reduced pressure. PubMed:Acute and subchronic toxicity study of Euphorbia hirta L. methanol extract in rats. PubMed:Chemical analysis, inhibition of biofilm formation and biofilm eradication potential of Euphorbia hirta L. against clinical isolates and standard strains. Hence, this study indicates that the E. hirta is effective against dengue virus . Let the concoction cool. However, these studies are inadequate to establish a clinical use of the plant. Particularly, the decoctions of leaves and aerial parts of the plant are commonly used for preparation. Sources: http://www.pchrd.dost.gov.ph/index.php/2012-05-23-07-46-36/2012-05-24-00-01-32/5296 … The samples were prepared in methanol and were passed through a Millipore filter (2.4 μ) prior to inject using a micro syringe. Euphorbia hirta is a host to many fungal pathogens and may as such act as a reservoir of pathogenic fungi, which can infect nearby susceptible crops. Take this decoction for one week. It is transmitted to humans by Aedes mosquitoes, mainly Aedes aegypti, an urban breeding mosquito . The Dosage of euphorbia tea Colisao municipal park found that mostly females 60–80 years of age with primary and secondary education generally use E. hirta extract to alleviate the symptoms of dengue and related bleeding episodes . Ayurvedic medical practitioners in India use euphorbia hirta to treat bronchial conditions. Eight full papers were entitled to the review; out of those, two studies focused on ethnobotanical surveys, three on animal experiments, one on human trial, and two on in vitro antiviral activities, and one was computational study. Though E. hirta is used as a folkloric plant in India , Pakistan , and Sri Lanka  for common ailments (fever and infection), no studies have been carried out in these countries to investigate its use against dengue. The salves made from Euphorbia hirta can be applied directly to the skin on burns, wounds, boils, rashes, and other marks. Along with the allopathic care, most people living in tropical and subtropical countries depend on folk/traditional medicine to alleviate dengue infection; in fact herbal medicines have been invaluable therapeutic agents going back to the earliest human civilizations . The remaining articles were initially screened by reading the “title” and thereafter the “abstracts.” Studies not satisfying the inclusion criteria (Section 2.2) were excluded at these stages. Come browse our large digital warehouse of free sample essays. Required fields are marked *. One additional article was identified by manually searching the reference lists and forward citations of included papers. E. hirta was also effective in increasing platelet counts in dengue patients of 30–55 age group . The symptoms of dengue range from a mild flu-like syndrome (known as dengue fever [DF]) to the most severe forms of the disease, which are characterized by coagulopathy, increased vascular permeability, and plasma leakage (dengue hemorrhagic fever [DHF]) which eventually leads to dengue shock syndrome (DS) . oz : US$ 190.23: For the right freight rate, shipping charges, conditions and delivery service, please visit our Webstore page! Only at TermPaperWarehouse.com" Furthermore, reduction of bleeding time in treated rats, compared to that of control rats, indicates an increase of platelet counts . Over 70% patients exhibited a platelet increase. The first dengue vaccine, Dengvaxia, has been licensed in 2015 for clinical practice . The leaves were air dried for 10 days then were kept in the hot air oven at 600c for 24-48 hrs. Out of the phytochemicals, quercetin exhibited the strongest binding with dengue targets. Wash them thoroughly. This site uses Akismet to reduce spam. Duringthe month of July and August plants were collected from abandonedlands near Kanchipuram. The dengue protease (2FOM) and dengue methyl transferase (2P40) have been selected as targets for binding assays. Add in boiling water and cook for ten minutes. A total of 90 g powdered Euphorbia hirta was used in the preparation of the extract. The parts of the plant that grow above the ground are used to make medicine. C. papaya has exhibited moderate or low inhibitory action against DENV2 growth in in vitro conditions . Many chemists prescribe extract of Euphorbia hirta for the treatment of asthma and for the treatments of other ailments. Article. Hence, in-depth analysis of immunomodulatory properties is fortified to establish the potential E. hirta on the alleviation of clinical symptoms of dengue. hirta. In addition, it was assumed that the anti-inflammatory potential of flavonoids may have contributed to the alleviation of flu-like symptoms in dengue patients following the treatment with E. hirta . The remaining articles were screened in the final stage by reading the full-text and those not meeting inclusion criteria were excluded. When using homeopathic remedies, consult your doctor. Thanks. Euphorbia hirta commonly known asTawa-Tawa is a plant used in folklore medicine in the Philippines for the treatment of dengue.  had used ethanol (intraperitoneal injection) induced thrombocytopenic Sprague-Dawley rats to evaluate the platelet increasing activity of E. hirta. Asthma Weed Snake Plant Euphorbia Hirta Seeds Packet of 200+ seeds from this very weedy, very common, medicinal herb! There have been approximately 30 different plant species found to have the potential to combat dengue, such as Andrographis paniculata [Hempedu Bumi (Malaysia)], Alternanthera philoxeroides (alligator weed), Carica papaya (papaya), Cladosiphon okamuranus (brown seaweed), and Momordica charantia [bitter melon, Peria (Malaysia)] . The fresh plants were washed and allowed to stand for about 5 minutes to remove remaining water. Collectively, the hemostatic potential of E. hirta was validated by this study and these properties are prudent in managing dengue infection. Euphorbia hirta commonly known as Tawa-Tawa is a plant used in folklore medicine in the Philippines for the treatment of dengue. View. One of authors (botanist Ouattara Katinan Etienne) was … Names of Euphorbia Hirta in various languages of the world are also given. Decoctions of leaves and bark are popularly administrated for dengue . It is a popular folkloric plant in other countries like India, Sri Lanka, Malaysia, Java, and Vietnam . It is estimated that around 50 million cases occur each year and more than 2.5 billion of people are at risk of infection . A survey conducted in 3 different indigenous communities in the island municipality of Anda, Mt. Put the leaves in a boiling pot and add water. This review study may be utilized for the identification and preparation of a monograph of Euphorbia hirta. In Euphorbia hirta the best results were observed in It was assumed that these compounds individually or synergistically may have contributed to antidengue activity . Conversely, the ethanol extract of E. hirta under in vitro condition demonstrated an 85% inhibition of plaque forming capacity of dengue virus serotype 1 (DENV-1)  and 34.7% inhibition of virus serotype 2 (DENV-2) . A. were detected in Euphorbia hirta plants in coconut plantations. The following inclusion criteria were used: (a) ethnobotanical studies based on use of E. hirta against dengue, (b) in vivo studies investigating the platelet increasing, white blood cell increasing and membrane stabilization potential of E. hirta, tested on laboratory animals such as mice, rats, and rabbits, (c) in vitro cell culture studies conducted against dengue viruses, (d) molecular docking studies involving the interaction between phytochemicals of E. hirta and dengue virus proteins, and (e) studies published before 31 October 2017. Ingredients Euphorbia hirta plant (15-30 gm), Water (1000 ml) Process Take Fresh whole plants of Euphorbia hirta. Dispose the leaves and stalks. Extract preparation The plant E. hirta grows upto a height of 40cm tall and it can also be seen lying down. Additional articles were obtained manually using the reference lists of included articles. modulates nonfunctional and functional immune responses of rats,”, P. Ranasinghe, P. Ranasinghe, W. P. Kaushalya M. Abeysekera et al., “In vitro erythrocyte membrane stabilization properties of Carica papaya L. leaf extracts,”, S. Kumar, R. Malhotra, and D. Kumar, “Euphorbia hirta: Its chemistry, traditional and medicinal uses, and pharmacological activities,”, D. Moher, A. Liberati, J. Tetzlaff, D. G. Altman, and Prisma Group, “Preferred reporting items for systematic reviews and meta-analyses,”, G. Q. de Guzman, A. T. L. Dacanay, B. Increased rapidly, currently reaching pandemic levels [ 3 ] after removing duplicates the. Targets for binding assays treatment for dengue of effective treatment [ 7 ] the availability. 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